Adenoviruses remain the leading suspect, though no cause has been identified.

Enlarge / Adenoviruses remain the leading suspect, though no cause has been identified. (credit: Getty | BSIP)

The global tally of unexplained hepatitis cases in children has reached about 450, including 11 reported deaths, according to an update from the European Centre for Disease Prevention and Control.

The cases come from more than two dozen countries around the world, with about 14 countries reporting more than five cases. The countries with the largest case counts so far are the United Kingdom and the United States.

In the UK, officials have identified 163 cases in children under the age of 16, 11 of whom required liver transplants. Last week, the US Centers for Disease Control reported 109 cases under investigation in children under the age of 10 from 25 states. Of those cases, 14 percent required liver transplants, and five children died.

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